Billboard Music Awards - 1986
- Top Adult Contemporary Single, "Words Get in the Way"
- Top New Pop Artist (Combined LP's & Singles)
- Top Pop Singles Artist (Duo/Group

Performance Magazine - 1988
- "Female Vocalist of the Year"

American Music Awards - 1989
- Favorite Pop/Rock Band/Duo/Group
American Billboard Award
- Songwriter Of The Year

MTV Video Music Awards - 1990
- International Viewer's Choice Awards—MTV Internacional, "Oye mi Canto (Hear my Voice)"

BMI - 1991
- Songwriter of The Year

Premio Lo Nuestro a la Musica Latina - 1992
- Lifetime Achievement Award

Star on the Hollywood Walk of Fame - 1993
Ellis Island Congressional Medal of Honor
Hispanic Heritage Award
Spirit of Hope Award

Grammy Award - 1994
- Best Latin Tropical Album, Mi Tierra
World Music Awards
- Best Selling Latin Performer
Musicares Person of The Year
Billboard Year End Charts
- Top Latin 50 Album Artist
- Top Latin 50 Album, Mi Tierra
- Top Tropical/Salsa Latin Artist
- Top Tropical/Salsa Latin Album, Mi Tierra

Billboard Music Awards - 1995
- Best Music Video of The Year, "Everlasting Love"
Billboard Year End Charts
- Top Tropical/Salsa Latin Artist
- Top Tropical/Salsa Latin Album, Mi Tierra

American Music Award - 1997
- Best Female Latin Artist
BMI Prestigious President's Award
Induction to the Songwriter's Hall of Fame

Amigo Music Awards (Spain) - 1998
- Best Latin Female Artist 

ALMA Award - 1999
- Outstanding Music Video, "Heaven's What I Feel"
- Outstanding Host in a Variety/Music/Comedy Special or Series, "The World Music Awards"
- Ricardo Montalban Lifetime Achievement Award
Billboard Latin Music Award
- Best Latin Dance Club Play Track of the Year, "Oye!"
The 100 Greatest Women in Rock and Roll
- Ranked at #81

American Music Awards - 2000
- Award Of Merit
Blockbuster Award
- Favorite Song from a Movie, "Music Of My Heart"
Latin Grammy Award
- Best Music Video, "No Me Dejes de Querer"
Harry Chapin Memorial Humanitarian Award
Amigo Music Awards (Spain)
- Best Latin Singer
International Women’s Forum “Hall Of Fame” Award

Grammy Award - 2001
- Best Latin Tropical/Salsa Album, Alma Caribeña
Billboard Latin Music Award
- Best Tropical/Salsa Album, Alma Caribeña

The Buoniconti Fund Humanitarian Award - 2003

ARC Weekly Top 40 19th Top Pop Artist of the Past 25 Years - 2004
Billboard Latin Music Award
- Latin Pop Airplay Track of the Year, "Hoy"
Magic 106 Exceptional Woman of the Year Award

Billboard Latin Music Award - 2005
- Tropical Airplay Track of the Year, "Tu Fotografía"

11th Latin Female Artist Of The Year (America Top 100) - 2007

Dial Radio Award (Spain) - 2008
Billboard Latin Music Award
- Tropical Album of the Year, 90 Millas
- Tropical Airplay Track of the Year, "No Llores"
St. Jude Hospital for Children Humanitarian Award